Watch Marshawn Lynch go full Beast Mode to kick off Gruden Era 2.0

first_imgThe Raiders took the opening kick off and sliced and diced the Rams’ vaunted defense deep into the red zone.That’s when Beast Mode broke out right in front of the Black Hole.Beast mode back. pic.twitter.com/hQ2bKkOvpG— Dieter Kurtenbach (@dkurtenbach) September 11, 2018 You have to admire the Rams’ Aquib Talib for his commitment to getting this ball ripped from the mitts of Lynch. But Beast Mode wasn’t having it.Marshawn Lynch is taking you all with him. pic.twitter.com/AbCJOUJ …last_img read more

Read More »

Mailbag: are the Sharks better off without Erik Karlsson?

first_imgSAN JOSE — With just one month left on the schedule, the Sharks are closing the gap with the Calgary Flames for first place in the Pacific Division, setting the stage for an intriguing race over the last 16 games of the season.The Sharks pulled to within three points of the Flames on Sunday, earning a pair of wins without Erik Karlsson and Evander Kane. Though Kane is expected to rejoin the lineup soon, the uncertainty surrounding Karlsson’s latest setback is stirring anxiety in the fan base.W …last_img read more

Read More »

49ers need Seahawks loss Monday to stay NFC’s top seed, avoid playoff plummet

first_imgUpdate: The Seahawks beat the Vikings on Monday night, moving past the 49ers in the NFL West standings.—The 49ers’ exclusive hold on first place in the NFC West the past two months will slip away Monday night unless the Vikings can upset the Seahawks.A Seattle win would not only knock San Francisco out of sole possession of first place for the first time in 64 days, but the 49ers would fall to the No. 5 seed in the NFC playoff chase with four games remaining. However, if the Vikings …last_img read more

Read More »

Babbage’s Computer May Be Built

first_imgThe “Analytical Engine,” a 19th-century computer conceived by Charles Babbage, may finally be built 140 years after his death.  The remarkable contraption was to be powered by steam and would fill a warehouse, but the eccentric old man could not get the Royal Society to back it.  His idea, 100 years ahead of its time, would be a true general-purpose computer, able to solve any problem expressible in numerical algorithms.  It would take instructions with punched cards, operate a CPU, use memory, and print output, just like early computers in the mid 20th century.  Given the technology and parts available in the mid 19th century, however, it was a dream far in advance of its time.  His son tried but was unable to get the plans off the ground.  Others also attempted the project but failed.    The BBC News reported that interest is growing in bringing the “inspirational piece of equipment” to reality, for its historical interest if not for its ability to compete with modern computers.  “A hundred years ago, before computers were available, [Babbage] had envisaged this machine,” a leader of the effort said.  A real working model would answer “profound historical questions,” a historian of computer technology remarked; “Could there have been an information age in Victorian times?  That is a very interesting question.”  Now, with distributed planning and world-wide cooperation, Babbage’s historic computer might just become a reality.Too bad this contemporary of Darwin did not get his project off the ground.  If the information age had begun in Darwin’s day, perhaps it would have taken the steam out of the idea of random variation producing complexity.  Read our online biography of Charles Babbage – a Christian scholar who would have been comfortable with Intelligent Design theory – for a really entertaining look at a fascinating visionary whose ideas would eventually triumph and change the world.(Visited 8 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Read More »

Automatic Emergency Brake Found on Molecular Motor

first_imgIn this article, guest writer Ross Anderson (PhD, biochemistry professor) discusses a new finding about how an ’emergency brake’ works in one of the most vital of all molecular machines, ATP synthase. First, he explains the molecular rotary motor and what it does.Review of “Extrinsic conditions influence the self-association and structure of IF1, the regulatory protein of mitochondrial ATP synthase” by Boreikaite et al., PNAS.Evaluated by Ross S. Anderson, Ph.D.First let’s take a brief look at what the ATP synthase (here referred to simply as the Synthase) is and its importance to life. In eukaryotes the Synthase is located in the mitochondrial inner membrane. In prokaryotes, such as E. coli, it is located in the cell membrane as these organisms lack mitochondria.Why ATP Is ImportantAdenosine triphosphate (ATP) is one of several high-energy compounds used by all cells to drive reactions necessary for life. Without it, life as we know it would not be possible. While it is not the only high-energy compound in the cell, it is the one most widely used by cells. To carry out its moment-to-moment activities a cell must have a constant supply of ATP. Most of the cell’s ATP needs are supplied by the ATP synthase molecular motor.In eukaryotes, such as humans, the mitochondria are the “power houses” of the cell as these contain the Synthase. In order for the synthase to synthesize ATP, there must be a steady supply of oxygen. Oxygen is delivered to the cells via hemoglobin in the red blood cells. The oxygen is then transferred to another protein in the cell known as myoglobin (responsible for the red color of muscle), myoglobin then carries the oxygen to the mitochondria where it serves as an electron acceptor to form water. The electrons come from food molecules eaten by the organism. They are removed by a variety of metabolic pathways and given to electron-carrier molecules such as NAD+ and FAD to form NADH and FADH2, respectively.Optimizing the MotorsElectrons from FADH2 and NADH are then transferred to protein complexes also located in the inner mitochondrial membrane. As the electrons are passed from one protein complex to another and ultimately to oxygen, they are used to power what are termed proton “pumps” which pump protons (H+) out of the mitochondrial matrix (the inner most part of the mitochondria) to the intermembrane space (the space between the inner and outer membranes of the mitochondria). This sets up a proton gradient with a high concentration of protons outside (intermembrane space) and a lower concentration inside (matrix).As protons travel back into the matrix down the gradient, the potential energy in the gradient is used to synthesize ATP. The inner membrane is impermeable to the protons, so to reach the matrix, the protons must travel through the Synthase. As they travel through the synthase, they cause an internal rotor, called the γ subunit to rotate in increments of 120°. As the γ subunit rotates, its contacts with the α3β3 subunits that comprise the knob part of the Synthase protruding into the matrix, cause a series of conformational changes in the 3 β subunits leading to the binding of ADP + Pi, the synthesis of ATP, and the release of ATP.The Role of OxygenAs stated above, in order for the synthase to synthesize ATP, there must be an ample amount of oxygen. However, if the blood supply to an organ is blocked, ischemia, then oxygen delivery is compromised. Under such hypoxic conditions, the Synthase would tend to rotate in the reverse direction and degrade precious ATP. For cells of the heart, the brain and other highly aerobic organs this can be life-threatening. To prevent this from happening, a small polypeptide of variable length, depending on the organism, has been designed to become active and bind to the α3β3 and γ subunits in such a way as to prevent the γ subunit from rotating in reverse and consuming ATP. This polypeptide is called IF1 (inhibitory factor 1).Mitochondrial membranes are optimized to concentrate protons where the ATP synthase motors are. They, in turn, are aligned in pairs to optimize ATP production.An Automatic BrakeUnder hypoxic conditions (low oxygen), the pH of the cell decreases (becomes more acidic), and this causes the IF1 to form dimers which are active and bind to the F1 region of two adjacent Synthases and cross-link them. There is a modest investment of 2 ATP consumed per binding of an IF1, but the savings in ATP can be significant. If conditions return to normal, and the pH rises again, the IF1 dimers form inactive tetramers and higher oligomers. One might compare it to the “hill stopper” function found in many newer cars. This mechanism engages the brakes if it senses that the vehicle is starting to roll backwards down a hill. It stops the wheels, allowing the driver to shift gears without fear of rolling into something behind them.Interestingly, under hypoxic conditions the E coli Synthase is allowed to run in reverse and consume ATP to pump H+s out of the cell; i.e., there is not an IF1-like polypeptide. This is because bacteria use proton gradients for many other purposes, not just the making of ATP. Even under hypoxic conditions the maintenance of these gradients is essential. The bacteria can increase their yield of ATP under these conditions by greatly increasing their consumption of glucose, as ATP can be generated from glucose via the glycolytic pathway which does not require oxygen.The energy demands of eukaryotic cells are greater than prokaryotic cells. Consequently, it is imperative that their mitochondria be supplied with ample amounts of oxygen in order generate the necessary quantities of ATP. While eukaryotic cells also have pathways to generate ATP that do not require oxygen; e.g., glycolysis, these cannot generate the sustained quantities of ATP needed. Any situation that would lead to the consumption of ATP unnecessarily without getting useful work out of it would quickly threaten the life of the cell. Anyone can recognize the “hill stopper” function used in many cars is obviously a designed feature. Similarly, the IF1 is also a design feature in living things used to prevent the unwanted consumption of ATP. It had to be in place and fully functional with the first eukaryotic cells.Good Science Doesn’t Need Evolutionary SpeculationNow that we’ve briefly looked at the Synthase and IF1, and their roles in the cell, let’s look at the article in PNAS.This paper is a good example of scientific research carried out and reported without invoking an evolutionary perspective. No doubt the authors believe in evolution, but they refrained from mentioning it here. This illustrates that important research can be done without a belief in evolution to guide it as nowhere in the article did the authors refer to evolution as a guiding principle. Indeed, no mention of evolution was made.Science, as illustrated by this article, is well equipped to address three questions:What is it? The answer to this question is to provide merely descriptive details as to what it looks like, what kind of molecule is it etc. These authors answered this question quite easily in describing the structure of the bovine IF1; an 84 amino acid polypeptide that binds to the F1 region of ATP synthase and inhibits it.What does it do? This question addresses the function of the object of study. This question was also easily addressed by the authors which explained how this polypeptide binds to the F1 portion of the ATP synthase and how this leads to its inhibition. They discussed how pH, protein concentration and Ca2+ concentration influence the formation of active dimers from inactive tetramers.How does it do what it does? This question asks how the object carries out its function. This question, too, was addressed by the authors. Under low oxygen conditions, such as hypoxia due to ischemia, the pH in the mitochondria decrease, the electron carriers in the inner membrane of the mitochondria are no longer able to pass the electrons onto oxygen and thus become progressively reduced. This leads to a collapse of the proton motive force used to power the synthesis of ATP by the Synthase. Under these conditions, the Synthase tends to do the reverse reaction and degrade ATP to ADP and Pi, thus quickly depleting the ATP concentration of the cell. To prevent this from happening, the lowered pH destabilizes the tetrameric complex of IF1 causing it to be dismantled into the active dimeric form. The dimeric form binds to the F1 portion of the Synthase and interacts with both the α and β subunits as well as the γ Interaction with the γ subunit inhibits its rotation and thus prevents the Synthase from working in reverse to destroy ATP.All too often authors of books and journal articles introduce a fourth question into the mix after addressing the first three in some detail. The fourth question is: How did it come to be? Detailed answering of the first three questions leads the reader to unwittingly have confidence in the answers to this fourth question; they assume that the author(s) know what they are talking about and uncritically accept their answers. What many fail to understand is that in addressing the fourth question one steps out of the arena of science and into the arena of philosophy or worldview. To their credit these authors did not do that, but instead they treated the data and its interpretation as they should have without trying to prop up a belief in evolution.Dr. Anderson’s expertise is in the area of biochemistry and molecular biology. He has taught Biochemistry and helped to direct research projects of graduate and medical students at Baylor College of Medicine, Houston, TX. Dr. Anderson was a post-doctoral researcher in the Molecular Genetics Division of the Department of Ophthalmology at the Houston Neurosensory Center.Dr. Anderson was a member of both the undergraduate and graduate faculty at Lamar University, Beaumont, TX. There he taught and directed the research activities of undergraduates and Masters of Science degree candidates in Biology. Currently he is professor of biochemistry at The Master’s University in southern California.Dr. Anderson’s research interests include structure-function studies of DNA polymerizing enzymes and the synthesis and expression of synthetic human genes in bacterial hosts. He has authored or co-authored several publications in major, peer-reviewed journals. He is a member of the American Chemical Society and Sigma Xi Research Society.(Visited 456 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Read More »

S-noilite Fashion 18″ : due to hair loss theese extensions give me my confidence back defo buying more great

first_imgIt arrived more quickly than i believed.The price tag is genuinely inexpensive little bit on the shinny aspect when brushed and styled appears to be good.A different good piece for the low price.Isn’t going to glimpse real and colour doesn’t match the hair, really however.Thanks to hair reduction theese extensions give me my self-assurance back again defo obtaining extra wonderful. Won’t be able to hold out for it to looks incredible,due to hair loss theese extensions give me my confidence back again defo getting extra fantastic rate.S-noilite Fashion 18″(46cm) Curly Binding Tie up Ponytail Clip in Hair Extensions Extension One Piece Wrap Around Pony Tail 12 Colors Available (Light Brown) : I wouldn’t usually write a review but i thought i would this time as i am so pleased. The item came today (earlier than expected) in perfect condition.The hair piece is easy to use and just as described. They say you get what you pay for but i feel i have received everything and more for such an amazing price. Not as thick as it appears to be but pretty fantastic high quality.Not as straightforward to have on superior on the head as banana clip but even now stunning and pretty superior high-quality.It arrived more quickly than i believed.I hardly ever produce assessments but this time i have to. The ponytail is amazing, i had in no way bought synthetic hair b4 coz i thought hmm it will have to glance phony and so forth till now. This appears to be excellent, the hair is so comfortable n beautiful. I’ve worn the human micro loop hair extensions now for a 12 months but am going to eliminate them to give my very own hair some relaxation so i acquired these to use in the meantime, to be truthful this ponytail appears to be like and feels so substantially much better than the human hair. When acquiring i was expecting it to b not quite superior but imagined nevermind it is only a fiver, but wow i am amazed. 🙂 also, iv listened to phony hair shines n seems actual phony but guess what – this one shine just a lil little bit, just like my possess hair. And color (bleach blonde) is sooo natural as well, just like my personal.Amazing for price tag arrive two times following ordering.A different good piece for the low price.Not as thick as it appears to be but pretty fantastic high quality.Gorgeous hair extension/pony tail. Shipping and delivery was speedy 4/five days i feel. Remarkable good quality for the selling price.So straightforward to use and retains in position all day. Excellent color so no one has nevertheless guessed it is fake, which i adore. Will certainly be acquiring additional from this enterprise.Thanks to hair reduction theese extensions give me my self-assurance back again defo obtaining extra wonderful. Won’t be able to hold out for it to looks incredible,due to hair loss theese extensions give me my confidence back again defo getting extra fantastic rate.Gorgeous hair extension/pony tail. Shipping and delivery was speedy 4/five days i feel. Remarkable good quality for the selling price.So straightforward to use and retains in position all day. Excellent color so no one has nevertheless guessed it is fake, which i adore. Will certainly be acquiring additional from this enterprise.I utilised this for the very first time very last night, held very well, superior top quality and quite extensive. Was abit nervous as i have hardly ever utilized a hair piece but liked it.I hardly ever produce assessments but this time i have to. The ponytail is amazing, i had in no way bought synthetic hair b4 coz i thought hmm it will have to glance phony and so forth till now. This appears to be excellent, the hair is so comfortable n beautiful. I’ve worn the human micro loop hair extensions now for a 12 months but am going to eliminate them to give my very own hair some relaxation so i acquired these to use in the meantime, to be truthful this ponytail appears to be like and feels so substantially much better than the human hair. When acquiring i was expecting it to b not quite superior but imagined nevermind it is only a fiver, but wow i am amazed. 🙂 also, iv listened to phony hair shines n seems actual phony but guess what – this one shine just a lil little bit, just like my possess hair. And color (bleach blonde) is sooo natural as well, just like my personal.Amazing for price tag arrive two times following ordering.Captivated several a compliment and question as to no matter whether it was my genuine hair. Only situation is i would like the grip/comb was wider so as to get a far better grip to keep in area. If not i’m extremely happy with my purchase.I cannot think how rapidly this item was shipped i purchased late night time on 27/4/sixteen and it was sent on 28/4/sixteen packaging is conventional hair is gorgeous and delivered in a net to defend condition the clip would not glance fantastic but given that it has the tie for added aid i carnt visualize there will be a difficulty and what can you anticipate for the cost. This is an absolute barging incredibly joyful buyer.I utilised this for the very first time very last night, held very well, superior top quality and quite extensive. Was abit nervous as i have hardly ever utilized a hair piece but liked it.last_img read more

Read More »

Ohio Ag Net Podcast | Ep. 108 | HOLY COW! Dairy Farm Under Investigation and Outrageous Hay Prices

first_imgShare Facebook Twitter Google + LinkedIn Pinterest The 108th episode of the Ohio Ag Net Podcast, sponsored by AgriGold, includes hosts Matt Reese, Joel Penhorwood, and special guest Candace Lease. They discuss the investigations against Fair Oaks Farms after the undercover animal abuse video was made.Joel Penhorwood interviews sale organizer of the LaRue Horse and Tack Sale, Janeen Heilman about the crazy high prices of hay at the sale ($65/bale). Matt Reese speaks with our Between the Rows Farmers, Dylan Baer from Wood County and Nathan Brown from Highland County.last_img read more

Read More »

Incentives for winning medals at Asian Games

first_imgThe countdown for the Asian Games has begun.With the quadrennial extravaganza set to kick off from November 12, Samsung India announced its incentive programme for the medallists at the Asian Games during a felicitation ceremony on Wednesday.The extraordinary performers will get goods worth Rs 2.5 lakh from the company. The Commonwealth Games medallists also received the cash prizes for their efforts in Delhi.The Indian Olympic Association (IOA) secretary general Randhir Singh eulogised the CWG medallists and exuded confidence that India will come up with a similar performance at the Asian Games.” Indian athletes performed exceptionally well in almost all the events they participated in the Commonwealth Games.They won medals in some of the most competitive events and performance was good even in new sports like netball, lawn bowls and rugby sevens. I am looking forward to witness more of such performances from our athletes at the Asiad,” said Randhir at the event.Randhir also praised the government for sending the largest ever Indian contingent to China.” I am happy that the government approved a contingent comprising 609 athletes which also includes 249 female athletes. This will surely motivate our athletes to give their best at the Games,” he said.Brimming with confidence after their successful run at the Delhi Games, hockey captain Rajpal Singh and boxer Suranjoy Singh sounded confident of winning medals for the country.Rajpal said that there are certain areas where the team still needs to improve but the players are really motivated to do well.” We are satisfied with our performance as we played well against the top teams in Delhi.advertisementYes, there are certain areas where we need to work, but we expect to go there with a positive attitude. We are pitted against Japan and Pakistan in our pool.Both the teams are strong so let’s see how successful we will be,” Rajpal told MAIL TODAY . ” We will also focus to qualify for the London Olympics to be held in 2012. The team is trying its best to reduce the errors as the penalty corner conversion needs to be improved if we want to win big matches,” he said.Discussing the newly introduced Global Positioning System ( GPS) in hockey, Rajpal said the use of technology would surely help in improving their game.Commonwealth Games gold medallist Suranjoy feels that India has a very good chance to win more medals at Asian Games. ” All the boxers are training very hard. I hope to win this time as well as after the Games I got enthused to improve my record. The competition in China is surely higher than the CWG but all the boxers are working hard to win medals,” Suranjoy said.Akhil, who is not part of the Asiad squad, backed Suranjoy and said that the pugilists have been through a tough training regime which leaves them with a good chance to bag some medals in Guangzhou.” India won a gold at the 1998 Asian Games and we want to repeat the feat in this edition. I feel India has produced some of the best boxers in the recent past and boxing is becoming a popular sport in the country. Good performance by our boxers has really helped the sport grow faster,” Akhil said.World Champion wrestler and CWG gold winner Sushil, who has pulled out of the Asian Games due to injuries, said the wrestling team is capable enough to do better even in his absence.” Wrestling team is in a great shape. All of them are working hard and let’s hope they get some medals too,” said Sushil.last_img read more

Read More »

William Shatner Jann Arden first Indigenous NHL player among 125 appointments to

first_imgAdvertisement Armstrong, who says she is “thrilled and honoured” with the recognition, remembers a time when she had to fight with editors and publishers to cover the issue she has dedicated her career to.Canadian journalist, filmmaker and human rights activist Sally Armstrong will be made an Officer of the Order of Canada. (Andy Hincenbergs/ CBC)She broke the story of how women were being gang-raped during the conflict in the former Yugoslavia for Homemaker’s magazine, bringing an issue she says was ignored into the spotlight. Twitter Advertisement Login/Register With: Advertisement LEAVE A REPLY Cancel replyLog in to leave a comment Facebook Canada’s newly minted Governor General, Julie Payette, has announced 125 appointments to the Order of Canada in a list that includes famous faces such as William Shatner and Jann Arden as well as two former Supreme Court justices and the Catholic priest Father John Walsh.Since its inception in 1967, almost 7,000 people from all walks of life have been invested into the Order of Canada. This year’s nominees will be awarded their honours at ceremonies to take place later in the year. Dates have not been set.Journalist and documentary filmmaker Sally Armstrong, who also happens to be the mother of CBC host Peter Armstrong, will be made an Officer of the Order for her groundbreaking work “highlighting human rights and the struggles of women in the world’s conflict zones.”last_img read more

Read More »